General description

Cryo-EM structure of the full agonist isoprenaline-bound beta2 adrenergic receptor-Gs protein complex.


Receptor name: Beta-2 adrenergic receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.8

Effector protein: G: α β γ (A B G)

Other protein: Nb35 nanobody (N)

Non-peptide ligand code: 5FW (R)

MD preparation


Number of mutations: 9

List of mutations: (R)G16R (R)E27Q (R)C77V (R)E122W (R)C125V (R)N187E (R)C265A (R)C285A (R)C327S


Name: Beta-2 adrenergic receptor

Organism: Homo sapiens

Uniprot: P07550

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Bos taurus

Uniprot: P62871

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Bos taurus

Uniprot: P63212


Title: Different Conformational Responses of the beta2-Adrenergic Receptor-Gs Complex upon Binding of the Partial Agonist Salbutamol or the Full Agonist Isoprenaline

Authors: Yang, F., Ling, S.L., Zhou, Y.X., Zhang, Y.N., Lv, P., Liu, S.L., Fang, W., Sun, W.J., Hu, L.Y.A., Zhang, L., Shi, P., Tian, C.

Published: Natl Sci Rev (2020)

Other protein (not shown in structure)

Name: Nb35 nanobody (N)

Organism: Lama glama

Receptor TM helicies
TM regions (from OPM database)

Receptor TM Region

Additional info

Membrane Thickness: 32.1 ± 1 Å

Tilt: Tilt ± Tilt Range°

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