GLP-1R-Gs complex structure with a small molecule full agonist

PDB ID: 7C2E RCSB | OPM

Receptor name: Glucagon-like peptide 1 receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 4.2

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Non-peptide ligand code: FFR (R)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Glucagon-like peptide 1 receptor

Organism: Homo sapiens

Uniprot: P43220

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structural insights into the activation of GLP-1R by a small molecule agonist.

Authors: Ma H, Huang W, Wang X, Zhao L, Jiang Y, Liu F, Guo W, Sun X, Zhong W, Yuan D, Xu HE

Published: Cell Res (2020)

Name: Nanobody 35

Organism: Lama glama

TM regions (from OPM database)

TM1(143-167),TM2(178-198),TM3(227-251),TM4(266-291),TM5(303-329),TM6(346-371),TM7(383-405)

Additional info

Membrane Thickness: 31 ± 1.6 Å

Tilt: 17 ± 0°