Structure of human SMO-Gi complex with 24(S),25-EC

PDB ID: 6XBM RCSB | OPM

Receptor name: Smoothened homolog

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Frizzled / F

Resolution [Å]: 3.1

Effector protein: G: α β γ (A B G)

Other protein: scFv16

Non-peptide ligand code: CO1 (R)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Smoothened homolog

Organism: Homo sapiens

Uniprot: Q99835

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Sterols in an intramolecular channel of Smoothened mediate Hedgehog signaling.

Authors: Qi X, Friedberg L, De Bose-Boyd R, Long T, Li X

Published: Nat Chem Biol (2020)

Name: scFv16

Organism: Mus musculus

TM regions (from OPM database)

TM1(232-253),TM2(265-285),TM3(313-336),TM4(359-378),TM5(398-420),TM6(450-471),TM7(516-536)

Additional info

Membrane Thickness: 29.8 ± 1 Å

Tilt: 6 ± 1°