General description

Non peptide agonist CHU-128, bound to Glucagon-Like peptide-1 (GLP-1) Receptor

PDB ID: 6X19 RCSB | OPM

Receptor name: Glucagon-like peptide 1 receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 2.1

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Non-peptide ligand code: UK1 (R)


MD preparation

Mutations

Number of mutations: 0

List of mutations: None

Receptor
Receptor

Name: Glucagon-like peptide 1 receptor

Organism: Homo sapiens

Uniprot: P43220

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

References

Title: Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

Authors: Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, ล enel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D

Published: Mol Cell (2020)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Lama glama

Receptor TM helicies
TM regions (from OPM database)

TM1(143-164),TM2(179-200),TM3(224-249),TM4(268-290),TM5(305-329),TM6(345-370),TM7(382-405)

Additional info

Membrane Thickness: 28.2 ± 1.4 Å

Tilt: 17 ± 0°


Back to table.