GLP-1 peptide hormone bound to Glucagon-Like peptide-1 (GLP-1) Receptor

PDB ID: 6X18 RCSB | OPM

Receptor name: Glucagon-like peptide 1 receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 2.1

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Peptide ligand: Glucagon (P)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Glucagon-like peptide 1 receptor

Organism: Homo sapiens

Uniprot: P43220

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Differential GLP-1R Binding and Activation by Peptide and Non-peptide Agonists.

Authors: Zhang X, Belousoff MJ, Zhao P, Kooistra AJ, Truong TT, Ang SY, Underwood CR, Egebjerg T, Šenel P, Stewart GD, Liang YL, Glukhova A, Venugopal H, Christopoulos A, Furness SGB, Miller LJ, Reedtz-Runge S, Langmead CJ, Gloriam DE, Danev R, Sexton PM, Wootten D

Published: Mol Cell (2020)

Name: Nanobody 35

Organism: Lama glama

TM regions (from OPM database)

TM1(143-164),TM2(179-200),TM3(224-249),TM4(268-290),TM5(303-329),TM6(349-373),TM7(382-405)

Additional info

Membrane Thickness: 29.8 ± 1 Å

Tilt: 15 ± 0°