Cryo-EM structure of the human chemokine receptor CCR6 in complex with CCL20 and a Go protein

PDB ID: 6WWZ RCSB | OPM

Receptor name: C-C chemokine receptor type 6

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.3

Effector protein: G: α β γ (A B Y)

Other protein: scFv16

Peptide ligand: C-C motif chemokine 20 (C)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: C-C chemokine receptor type 6

Organism: Homo sapiens

Uniprot: P51684

Name: Guanine nucleotide-binding protein G(o) subunit alpha

Organism: Homo sapiens

Uniprot: P09471

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Rattus norvegicus

Uniprot: P54311

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Rattus norvegicus

Uniprot: P59768

Title: Structural basis for chemokine receptor CCR6 activation by the endogenous protein ligand CCL20.

Authors: Wasilko DJ, Johnson ZL, Ammirati M, Che Y, Griffor MC, Han S, Wu H

Published: Nat Commun (2020)

Name: scFv16

Organism: Mus musculus

TM regions (from OPM database)

TM1( 47-73),TM2( 82-104),TM3( 116-141),TM4( 164-185),TM5( 210-235),TM6( 256-279),TM7( 296-319)

Additional info

Membrane Thickness: 33.8 ± 0.8 Å

Tilt: 3 ± 2°