GCGR-Gs signaling complex bound to a designed glucagon derivative

PDB ID: 6WPW RCSB | OPM

Receptor name: Glucagon receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 3.1

Effector protein: G: α β γ (C D G)

Peptide ligand: Glucagon derivative ZP3780 (P)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Glucagon receptor

Organism: Homo sapiens

Uniprot: P47871

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structural insights into differences in G protein activation by family A and family B GPCRs.

Authors: Hilger D, Kumar KK, Hu H, Pedersen MF, O'Brien ES, Giehm L, Jennings C, Eskici G, Inoue A, Lerch M, Mathiesen JM, Skiniotis G, Kobilka BK

Published: Science (2020)

TM regions (from OPM database)

TM1(141-165),TM2(175-196),TM3(225-247),TM4(266-288),TM5(301-323),TM6(347-372),TM7(377-403)

Additional info

Membrane Thickness: 30.6 ± 1 Å

Tilt: 16 ± 0°