Human secretin receptor Gs complex

PDB ID: 6WI9 RCSB | OPM

Receptor name: Secretin receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 4.3

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Peptide ligand: Secretin (P)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Secretin receptor

Organism: Homo sapiens

Uniprot: P47872

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structure and dynamics of the active Gs-coupled human secretin receptor.

Authors: Dong M, Deganutti G, Piper SJ, Liang YL, Khoshouei M, Belousoff MJ, Harikumar KG, Reynolds CA, Glukhova A, Furness SGB, Christopoulos A, Danev R, Wootten D, Sexton PM, Miller LJ

Published: Nat Commun (2020)

Name: Nanobody 35

Organism: Lama glama

TM regions (from OPM database)

TM1(142-167),TM2(175-195),TM3(217-239),TM4(255-276),TM5(292-315),TM6(341-356),TM7(368-391)

Additional info

Membrane Thickness: 30.2 ± 0.8 Å

Tilt: 12 ± 1°