CryoEM Structure of the glucagon receptor with a dual-agonist peptide
Receptor name: Glucagon receptor
Receptor chain: R
Receptor organism: Homo sapiens
Family / Class: Secretin / B1
Resolution [Å]: 3.4
Effector protein: G: α β γ (A B C)
Other protein: Nanobody 35
Peptide ligand: Dual-agonist peptide 15 (E)
Number of mutations: 0
List of mutations: None
Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short
Organism: Homo sapiens
Uniprot: P63092
Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1
Organism: Homo sapiens
Uniprot: P62873
Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2
Organism: Homo sapiens
Uniprot: P59768
Title: Cryo-electron microscopy structure of the glucagon receptor with a dual-agonist peptide.
Authors: Chang R, Zhang X, Qiao A, Dai A, Belousoff MJ, Tan Q, Shao L, Zhong L, Lin G, Liang YL, Ma L, Han S, Yang D, Danev R, Wang MW, Wootten D, Wu B, Sexton PM
Published: J Biol Chem (2020)
Name: Nanobody 35
Organism: Lama glama
TM regions (from OPM database)
TM1(144-166),TM2(174-193),TM3(228-249),TM4(264-284),TM5(304-326),TM6(380-404)
Additional info
Membrane Thickness: 28.6 ± 2 Å
Tilt: 5 ± 1°
Back to table.