Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

PDB ID: 6WHA RCSB | OPM

Receptor name: 5-hydroxytryptamine receptor 2A

Receptor chain: A

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.4

Effector protein: G: α β γ (B C D)

Fusion protein: Soluble cytochrome b562

Other protein: single Fab chain (svFv16)

Non-peptide ligand code: U0G (A)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: 5-hydroxytryptamine receptor 2A

Organism: Homo sapiens

Uniprot: P28223

Fusion protein

Name: Soluble cytochrome b562

Organism: Escherichia coli

Uniprot: P0ABE7

Name: G subunit q (Gi2-mini-Gq chimeric)

Organism: Homo sapiens

Uniprot: P28223

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structure of a Hallucinogen-Activated Gq-Coupled 5-HT2A Serotonin Receptor

Authors: Kim K, Che T, Panova O, Shoichet B.K, Skiniotis G, Roth B.L.

Published: Cell (2020)

Name: single Fab chain (svFv16)

Organism: Homo sapiens

TM regions (from OPM database)

TM1(86-96),TM2(112-136),TM3(146-171),TM4(194-215),TM5(232-256),TM6(323-345),TM7(360-380)

Additional info

Membrane Thickness: 31.8 ± 1 Å

Tilt: 9 ± 0°