Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane

PDB ID: 6VMS RCSB | OPM

Receptor name: D(2) dopamine receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.8

Effector protein: G: α β γ (A B C)

Fusion protein: Endolysin

Other protein: scFv16

Non-peptide ligand code: 08Y (R)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: D(2) dopamine receptor

Organism: Homo sapiens

Uniprot: P14416

Fusion protein

Name: Endolysin

Organism: Enterobacteria phage T4

Uniprot: D9IEF7

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Rattus norvegicus

Uniprot: P10824

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62874

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59769

Title: Structure of a D2 dopamine receptor-G-protein complex in a lipid membrane.

Authors: Yin J, Chen KM, Clark MJ, Hijazi M, Kumari P, Bai XC, Sunahara RK, Barth P, Rosenbaum DM

Published: Nature (2020)

Name: scFv16

Organism: Homo sapiens

TM regions (from OPM database)

TM1(36-56),TM2(72-96),TM3(105-130),TM4(154-175),TM5(187-210),TM6(373-398),TM7(406-428)

Additional info

Membrane Thickness: 31.4 ± 2 Å

Tilt: 9 ± 3°