neurotensin receptor and arrestin2 complex

PDB ID: 6UP7 RCSB | OPM

Receptor name: Neurotensin receptor type 1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 4.2

Effector protein: Arrestin (B)

Other protein: Nanobody 35, Receptor activity-modifying protein 2

Peptide ligand: ARG-ARG-PRO-TYR-ILE-LEU (C)

Non-peptide ligand code: PIO (R) UNK (V)

MD preparation

Number of mutations: 7

List of mutations: (B)C59V (B)C125S (B)C140L (B)C150V (B)C242V (B)C251V (B)C269S

Receptor

Name: Neurotensin receptor type 1

Organism: Homo sapiens

Uniprot: P30989

Name: Beta-arrestin-1

Organism: Homo sapiens

Uniprot: P49407

Title: Structure of the neurotensin receptor 1 in complex with β-arrestin 1.

Authors: Huang W, Masureel M, Qu Q, Janetzko J, Inoue A, Kato HE, Robertson MJ, Nguyen KC, Glenn JS, Skiniotis G, Kobilka BK

Published: Nature (2020)

Name: Nanobody 35, Receptor activity-modifying protein 2

Organism: Lama glama, Homo sapiens

Uniprot: O60896

TM regions (from OPM database)

TM1( 60-82),TM2( 104-131),TM3( 140-168),TM4( 184-206),TM5( 236-265),TM6( 301-324),TM7( 343-364)

Additional info

Membrane Thickness: 31 ± 1.4 Å

Tilt: 32 ± 1°