GPCR-Beta arrestin structure in lipid bilayer

PDB ID: 6U1N RCSB | OPM

Receptor name: Vasopressin V2 receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 4.0

Effector protein: Arrestin (C)

Other protein: Fab30 heavy chain, Fab30 light chain, unidentified peptide

Non-peptide ligand code: 2CU (R)

MD preparation

Number of mutations: 7

List of mutations: (C)C59V (C)C125S (C)C140L (C)C150V (C)C242V (C)C251V (C)C269S

Receptor

Name: Vasopressin V2 receptor

Organism: Homo sapiens

Uniprot: P08172

Name: Beta-arrestin-1

Organism: Homo sapiens

Uniprot: P63092

Title: Structure of the M2 muscarinic receptor-β-arrestin complex in a lipid nanodisc.

Authors: Staus DP, Hu H, Robertson MJ, Kleinhenz ALW, Wingler LM, Capel WD, Latorraca NR, Lefkowitz RJ, Skiniotis G

Published: Nature (2020)

Name: Fab30 heavy chain, Fab30 light chain, unidentified peptide

Organism: Lama glama, Homo sapiens

Uniprot: O60896

TM regions (from OPM database)

TM1( 22-45),TM2( 62-85),TM3( 92-119),TM4( 141-162),TM5( 185-211),TM6( 385-408),TM7( 421-442)

Additional info

Membrane Thickness: 30.2 ± 1 Å

Tilt: 19 ± 0°