Phosphorylated turkey beta1 adrenoceptor with bound agonist formoterol coupled to arrestin-2 in lipid nanodisc.

PDB ID: 6TKO RCSB | OPM

Receptor name: Beta-1 adrenergic receptor

Receptor chain: A

Receptor organism: Meleagris gallopavo

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.3

Effector protein: Arrestin (B)

Other protein: Fab30 heavy chain, Fab30 light chain, NB80

Non-peptide ligand code: H98 (A)

MD preparation

Number of mutations: 12

List of mutations: (A)S32G (A)M44C (A)M90V (A)V103C (A)C116L (A)E130W (A)D322K (A)F327A (A)F338M (B)M1G (B)L68C (B)R169E

Receptor

Name: Beta-1 adrenergic receptor

Organism: Meleagris gallopavo

Uniprot: P07700

Name: Beta-arrestin-1

Organism: Homo sapiens

Uniprot: P63092

Title: Molecular basis of β-arrestin coupling to formoterol-bound β1-adrenoceptor

Authors: Lee Y, Warne T, Nehme R, Pandey S, DwivediAgnihotri H, Chaturvedi M, Edwards PC, Garcia-Nafria J, Leslie AGW, Shukla AK, Tate CG

Published: Nature (2020)

Name: Fab30 heavy chain, Fab30 light chain, NB80

Organism: Lama glama, Homo sapiens

Uniprot: O60895

TM regions (from OPM database)

TM1( 44-64),TM2( 78-103),TM3( 112-137),TM4( 158-179),TM5( 206-228),TM6( 292-315),TM7( 323-344)

Additional info

Membrane Thickness: 30.6 ± 1.2 Å

Tilt: 4 ± 0°