A complex structure of arrestin-2 bound to neurotensin receptor 1

PDB ID: 6PWC RCSB | OPM

Receptor name: Neurotensin receptor type 1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 4.9

Effector protein: Arrestin (A)

Other protein: Fab30 heavy chain, Fab30 light chain,

Peptide ligand: Neurotensin peptide (B)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Neurotensin receptor type 1

Organism: Homo sapiens

Uniprot: P30989

Name: Beta-arrestin-1

Organism: Rattus norvegicus

Uniprot: P29066

Title: A complex structure of arrestin-2 bound to a G protein-coupled receptor.

Authors: Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H

Published: Cell Res (2019)

Name: Fab30 heavy chain, Fab30 light chain,

Organism: Synthetic construct

TM regions (from OPM database)

TM1(61-80),2(105-129),3(139-171),TM4( 183-200),TM5( 239-269),TM6( 295-320),TM7( 345-367)

Additional info

Membrane Thickness: 30.6 ± 1.2 Å

Tilt: 39 ± 1°