PAC1 GPCR Receptor complex

PDB ID: 6P9Y RCSB | OPM

Receptor name: Pituitary adenylate cyclase-activating polypeptide type I receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 3.0

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Peptide ligand: Pituitary adenylate cyclase-activating polypeptide (P)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Pituitary adenylate cyclase-activating polypeptide type I receptor

Organism: Homo sapiens

Uniprot: P41586

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.

Authors: Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D

Published: Mol Cell (2020)

Name: Nanobody 35

Organism: Lama glama

TM regions (from OPM database)

TM1( 153-175),TM2( 188-209),TM3( 224-252),TM4( 268-287),TM5( 304-329),TM6( 347-369),TM7( 380-401)

Additional info

Membrane Thickness: 32.2 ± 1.6 Å

Tilt: 18 ± 1°