Structure of the Rhodopsin-Transducin-Nanobody Complex

PDB ID: 6OYA RCSB | OPM

Receptor name: Rhodopsin

Receptor chain: R

Receptor organism: Bos taurus

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.3

Effector protein: G: α β γ (A B G)

Other protein: Camelid antibody VHH fragment

Non-peptide ligand code: RET (R)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Rhodopsin

Organism: Bos taurus

Uniprot: P02699

Name: Guanine nucleotide-binding protein G(t) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.

Authors: Gao Y, Hu H, Ramachandran S, Erickson JW, Cerione RA, Skiniotis G

Published: Mol Cell (2019)

Name: Camelid antibody VHH fragment

Organism: Lama glama

TM regions (from OPM database)

TM1( 38-60),TM2( 73-99),TM3( 111-134),TM4( 151-173),TM5( 202-224),TM6( 253-274),TM7( 286-309)

Additional info

Membrane Thickness: 29.8 ± 1.2 Å

Tilt: 7 ± 1°