human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in non-canonical conformation (NC state)

PDB ID: 6OSA RCSB | OPM

Receptor name: Neurotensin receptor type 1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.0

Effector protein: G: α β γ (A B C)

Peptide ligand: JMV449 (L)

MD preparation

Number of mutations: 1

List of mutations: (R)A85L

Receptor

Name: Neurotensin receptor type 1

Organism: Homo sapiens

Uniprot: P30989

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Bos taurus

Uniprot: P04695

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Bos taurus

Uniprot: P62871

Name: Guanine nucleotide-binding protein G(T) subunit gamma-T1

Organism: Bos taurus

Uniprot: P02698

Title: Conformational transitions of a neurotensin receptor 1-G_i1 complex.

Authors: Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G

Published: Nature (2019)

TM regions (from OPM database)

TM1( 60-86),TM2( 105-129),TM3( 139-164),TM4( 187-206),TM5( 233-257),TM6( 305-325),TM7( 344-363)

Additional info

Membrane Thickness: 31 ± 1 Å

Tilt: 5 ± 0°