Non-peptide agonist (TT-OAD2) bound to the Glucagon-Like peptide-1 (GLP-1) Receptor

PDB ID: 6ORV RCSB | OPM

Receptor name: Glucagon-like peptide 1 receptor

Receptor chain: E

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.0

Effector protein: G: α β γ (A B C)

Other protein: Nanobody 35

Non-peptide ligand code: N2V

MD preparation

Number of mutations: 0

List of mutations: None

Chains IDs renamed from (RP AP BP GP) to (E A B C).

Receptor

Name: Glucagon-like peptide 1 receptor

Organism: Homo sapiens

Uniprot: P43220

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Activation of the GLP-1 receptor by a non-peptidic agonist.

Authors: Zhao P, Liang YL, Belousoff MJ, Deganutti G, Fletcher MM, Willard FS, Bell MG, Christe ME, Sloop KW, Inoue A, Truong TT, Clydesdale L, Furness SGB, Christopoulos A, Wang MW, Miller LJ, Reynolds CA, Danev R, Sexton PM, Wootten D

Published: Nature (2020)

Name: Nanobody 35

Organism: Mus musculus

TM regions (from OPM database)

TM1( 143-165),TM2( 179-200),TM3( 224-249),TM4( 268-290),TM5( 304-329),TM6( 350-371),TM7( 381-405)

Additional info

Membrane Thickness: 30.6 ± 1.2 Å

Tilt: 12 ± 0°