Muscarinic acetylcholine receptor 2-Go complex

PDB ID: 6OIK RCSB | OPM

Receptor name: Muscarinic acetylcholine receptor M2

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.6

Effector protein: G: α β γ (A B G)

Other protein: Antibody fragment

Non-peptide ligand code: 2CU (R) IXO (R)

MD preparation

Number of mutations: 7

List of mutations: (R)N3A (R)N6D (R)N9D (A)E9D (A)R10K (A)L13V (A)A18M

Receptor

Name: Muscarinic acetylcholine receptor M2

Organism: Homo sapiens

Uniprot: P08172

Name: Guanine nucleotide-binding protein G(o) subunit alpha

Organism: Homo sapiens

Uniprot: P09471

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

Authors: Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK

Published: Science (2019)

Name: Antibody fragment

Organism: Homo sapiens

TM regions (from OPM database)

TM1( 22-46),TM2( 61-86),TM3( 94-119),TM4( 140-165),TM5( 183-207),TM6( 388-412),TM7( 417-442)

Additional info

Membrane Thickness: 30.6 ± 1 Å

Tilt: 6 ± 3°