Muscarinic acetylcholine receptor 1-G11 protein complex

PDB ID: 6OIJ RCSB | OPM

Receptor name: Muscarinic acetylcholine receptor M1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.3

Effector protein: G: α β γ (A B G)

Other protein: Antibody fragment

Non-peptide ligand code: IXO (R) Y01 (R)

MD preparation

Number of mutations: 3

List of mutations: (R)N2Q (R)N12Q (R)N110Q

Receptor

Name: Muscarinic acetylcholine receptor M1

Organism: Homo sapiens

Uniprot: P11229

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1???

Organism: Homo sapiens

Uniprot: P29992

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structures of the M1 and M2 muscarinic acetylcholine receptor/G-protein complexes.

Authors: Maeda S, Qu Q, Robertson MJ, Skiniotis G, Kobilka BK

Published: Science (2019)

Name: Antibody fragment

Organism: Synthetic construct

TM regions (from OPM database)

TM1( 24-48),TM2( 64-87),TM3( 95-120),TM4( 145-167),TM5( 185-206),TM6( 367-390),TM7( 395-418)

Additional info

Membrane Thickness: 30.6 ± 2.8 Å

Tilt: 6 ± 0°