Cryo-EM structure of a class A GPCR

PDB ID: 6LFM RCSB | OPM

Receptor name: C-X-C chemokine receptor type 2

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.5

Effector protein: G: α β γ (A B C)

Other protein: scFv16

Peptide ligand: Interleukin-8 (D,E)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: C-X-C chemokine receptor type 2

Organism: Homo sapiens

Uniprot: P25025

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structural basis of CXC chemokine receptor 2 activation and signalling

Authors: Liu K, Wu L, Yuan S, WU M, XU Y, SUN Q, LI S, Zhao S, Hua T, Liu ZJ

Published: Nature (2020)

Name: scFv16

Organism: Homo sapiens

TM regions (from OPM database)

TM1( 50-70),TM2( 86-108),TM3( 116-142),TM4( 164-183),TM5( 209-233),TM6( 250-273),TM7( 295-317)

Additional info

Membrane Thickness: 33.4 ± 0.8 Å

Tilt: 11 ± 1°