cryo-EM structure of alpha2BAR-GoA complex

PDB ID: 6K41 RCSB | OPM

Receptor name: Alpha-2B adrenergic receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 2.9

Effector protein: G: α β γ (A B G)

Fusion protein: Endolysin

Other protein: scFv

Non-peptide ligand code: CZX (R)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Alpha-2B adrenergic receptor

Organism: Homo sapiens

Uniprot: P18089

Fusion protein

Name: Endolysin

Organism: Enterobacteria phage RB59

Uniprot: P00720

Name: Guanine nucleotide-binding protein G(o) subunit alpha

Organism: Homo sapiens

Uniprot: P09471

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Mus musculus

Uniprot: P62874

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Activation of the α_2B adrenoceptor by the sedative sympatholytic dexmedetomidine.

Authors: Yuan D, Liu Z, Kaindl J, Maeda S, Zhao J, Sun X, Xu J, Gmeiner P, Wang HW, Kobilka BK

Published: Nat Chem Biol (2020)

Name: scFv

Organism: Mus musculus

TM regions (from OPM database)

TM1( 13-35),TM2( 49-74),TM3( 86-108),TM4( 130-148),TM5( 171-193),TM6( 373-393),TM7( 408-428)

Additional info

Membrane Thickness: 31.8 ± 1.4 Å

Tilt: 0 ± 1°