Coupling specificity of heterotrimeric Go to the serotonin 5-HT1B receptor

PDB ID: 6G79 RCSB | OPM

Receptor name: 5-hydroxytryptamine receptor 1B

Receptor chain: S

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.8

Effector protein: G: α β γ (A B G)

Non-peptide ligand code: EP5 (S)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: 5-hydroxytryptamine receptor 1B

Organism: Homo sapiens

Uniprot: P28222

Name: Guanine nucleotide-binding protein G(o) subunit alpha

Organism: Homo sapiens

Uniprot: P09471

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Cryo-EM structure of the serotonin 5-HT_1B receptor coupled to heterotrimeric G_o.

Authors: García-Nafría J, Nehmé R, Edwards PC, Tate CG

Published: Nature (2018)

TM regions (from OPM database)

TM1( 47-72),TM2( 87-111),TM3( 120-145),TM4( 166-184),TM5( 206-229),TM6( 316-337),TM7( 348-370)

Additional info

Membrane Thickness: 33 ± 2.2 Å

Tilt: 7 ± 1°