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General description

Crystal structure of the rhodopsin-mini-Go complex

PDB ID: 6FUF RCSB | OPM

Receptor name: Rhodopsin

Receptor chain: A

Receptor organism: Bos taurus

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.1

Effector protein: G: α (B)

Non-peptide ligand code: RET (A)


MD preparation

Mutations

Number of mutations: 11

List of mutations: (A)N2C (A)M257Y (A)D282C (B)A18G (B)G42D (B)E43N (B)A227D (B)G230D (B)L250D (B)I332A (B)V335I

Receptor
Receptor

Name: Rhodopsin

Organism: Bos taurus

Uniprot: P02699

Effector protein

Name: Guanine nucleotide-binding protein G(o) subunit alpha

Organism: Homo sapiens

Uniprot: P09471

References

Title: Crystal structure of rhodopsin in complex with a mini-G<sub>o</sub> sheds light on the principles of G protein selectivity.

Authors: Tsai CJ, Pamula F, Nehmé R, Mühle J, Weinert T, Flock T, Nogly P, Edwards PC, Carpenter B, Gruhl T, Ma P, Deupi X, Standfuss J, Tate CG, Schertler GFX

Published: Sci Adv (2018)

PubMed
Receptor TM helicies
TM regions (from OPM database)

TM1( 38-60),TM2( 73-99),TM3( 109-134),TM4( 153-173),TM5( 201-224),TM6( 253-274),TM7( 286-309)

Additional info

Membrane Thickness: 31 ± 1.2 Å

Tilt: 2 ± 3°


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