Mu Opioid Receptor-Gi Protein Complex

PDB ID: 6DDF RCSB | OPM

Receptor name: Mu-type opioid receptor

Receptor chain: R

Receptor organism: Mus musculus

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.5

Effector protein: G: α β γ (A B C)

Peptide ligand: DAMGO (D)

MD preparation

Number of mutations: 0

List of mutations: None

Receptor

Name: Mu-type opioid receptor

Organism: Mus musculus

Uniprot: P42866

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768

Title: Structure of the µ-opioid receptor-G_i protein complex.

Authors: Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK

Published: Nature (2018)

TM regions (from OPM database)

TM1( 69-91),TM2( 106-127),TM3( 138-162),TM4( 186-205),TM5( 227-251),TM6( 283-305),TM7( 313-336)

Additional info

Membrane Thickness: 31.4 ± 2.1 Å

Tilt: 2 ± 3°