Structure of the adenosine A2A receptor bound to an engineered G protein

PDB ID: 5G53 RCSB | OPM

Receptor name: Adenosine receptor A2a

Receptor chain: A

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.4

Effector protein: G: α (C)

Non-peptide ligand code: NEC (A)

MD preparation

Number of mutations: 8

List of mutations: (A)N154A (C)G49D (C)E50N (C)A249D (C)S252D (C)L272D (C)I372A (C)V375I

Receptor

Name: Adenosine receptor A2a

Organism: Homo sapiens

Uniprot: P29274

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Title: Structure of the adenosine A(2A) receptor bound to an engineered G protein.

Authors: Carpenter B, Nehmé R, Warne T, Leslie AG, Tate CG

Published: Nature (2016)

TM regions (from OPM database)

TM1( 8-28),TM2( 43-68),TM3( 76-104),TM4( 119-141),TM5( 174-200),TM6( 232-256),TM7( 267-288)

Additional info

Membrane Thickness: 33.6 ± 2.2 Å

Tilt: 16 ± 0°