Crystal structure of the beta2 adrenergic receptor-Gs protein complex

PDB ID: 3SN6 RCSB | OPM

Receptor name: Beta-2 adrenergic receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.2

Effector protein: G: α β γ (A B G)

Fusion protein: Endolysin

Other protein: Camelid antibody VHH fragment

Non-peptide ligand code: P0G (R)

MD preparation

Number of mutations: 4

List of mutations: (A)G86S (R)M96T (R)M98T (R)N187E

Receptor

Name: Beta-2 adrenergic receptor

Organism: Homo sapiens

Uniprot: P07550

Fusion protein

Name: Endolysin

Organism: Enterobacteria phage RB59

Uniprot: P00720

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Bos taurus

Uniprot: P04896

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Rattus norvegicus

Uniprot: P54311

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Bos taurus

Uniprot: P63212

Title: Crystal structure of the β2 adrenergic receptor-Gs protein complex.

Authors: Rasmussen SG, DeVree BT, Zou Y, Kruse AC, Chung KY, Kobilka TS, Thian FS, Chae PS, Pardon E, Calinski D, Mathiesen JM, Shah ST, Lyons JA, Caffrey M, Gellman SH, Steyaert J, Skiniotis G, Weis WI, Sunahara RK, Kobilka BK

Published: Nature (2011)

Name: Camelid antibody VHH fragment

Organism: Lama glama

TM regions (from OPM database)

TM1(32-56),TM2(71-95),TM3(104-129),TM4(149-171),TM5(198-220),TM6(275-298),TM7(306-326)

Additional info

Membrane Thickness: 31 ± 1.6 Å

Tilt: 8 ± 1°