General description

Cryo-EM structure of the human glucagon-like peptide-2 receptor-Gs protein complex


Receptor name: Glucagon-like peptide 2 receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 3.0

Effector protein: G: α β γ (A B G)

Other protein: Nanobody-35 (N)

Peptide ligand: Pro-glucagon (P)

MD preparation


Number of mutations: 2

List of mutations: (A)G226A,(A)A366S


Name: Glucagon-like peptide 2 receptor

Organism: Homo sapiens

Uniprot: Unspecified

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short


Uniprot: Unspecified

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Bos taurus

Uniprot: P62871

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Bos taurus

Uniprot: P63212


Title: A unique hormonal recognition feature of the human glucagon-like peptide-2 receptor.

Authors: Sun, W., Chen, L.N., Zhou, Q., Zhao, L.H., Yang, D., Zhang, H., Cong, Z., Shen, D.D., Zhao, F., Zhou, F., Cai, X., Chen, Y., Zhou, Y., Gadgaard, S., van der Velden, W.J.C., Zhao, S., Jiang, Y., Rosenkilde, M.M., Xu, H.E., Zhang, Y., Wang, M.W.

Published: Cell Res. (2020)

Other protein (not shown in structure)

Name: Nanobody-35 (N)

Organism: synthetic construct

Receptor TM helicies
TM regions (from OPM database)

Receptor TM Region

Additional info

Membrane Thickness: 31.4 ± 2 Å

Tilt: Tilt ± Tilt Range°

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