General description

Active human TGR5 complex with a synthetic agonist 23H


Receptor name: Bile acids receptor TGR5 in complex with stimulatory G protein

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.9

Effector protein: G: α β γ (A B G)

Fusion protein: Soluble cytochrome b562

Other protein: Nanobody 35

MD preparation


Number of mutations: 0

List of mutations: None


Name: Bile acids receptor TGR5 in complex with stimulatory G protein

Organism: Homo sapiens

Uniprot: Q8TDU6

Fusion protein

Name: Soluble cytochrome b562

Organism: Escherichia coli

Uniprot: P0ABE7

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Rattus norvegicus

Uniprot: P54311

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Bos taurus

Uniprot: P63213


Title: Cryo-EM structure of activated bile acids receptor TGR5 in complex with stimulatory G protein.

Authors: Chen G, Wang X, Ge Y, Ma L, Chen Q, Liu H, Du Y, Ye RD, Hu H, Ren R

Published: Signal Transduct Target Ther (2020)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Vicugna pacos

Receptor TM helicies
TM regions (from OPM database)


Additional info

Membrane Thickness: 31.4 ± 1.6 Å

Tilt: 4 ± 2°

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