General description

CryoEM Structure of the active Adrenomedullin 2 receptor G protein complex with adrenomedullin peptide


Receptor name: Calcitonin gene-related peptide type 1 receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 2.4

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Peptide ligand: Adrenomedullin peptide (P), Receptor activity-modifying protein 3 (E)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Calcitonin gene-related peptide type 1 receptor

Organism: Homo sapiens

Uniprot: Q16602

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Structure and Dynamics of Adrenomedullin Receptors AM<sub>1</sub> and AM<sub>2</sub> Reveal Key Mechanisms in the Control of Receptor Phenotype by Receptor Activity-Modifying Proteins.

Authors: Liang YL, Belousoff MJ, Fletcher MM, Zhang X, Khoshouei M, Deganutti G, Koole C, Furness SGB, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Danev R, Wootten D, Sexton PM

Published: ACS Pharmacol Transl Sci (2020)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Lama glama

Receptor TM helicies
TM regions (from OPM database)


Additional info

Membrane Thickness: 30.2 ± 1 Å

Tilt: 19 ± 0°

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