General description

A complex structure of arrestin-2 bound to neurotensin receptor 1


Receptor name: Neurotensin receptor type 1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 4.9

Effector protein: Arrestin (A)

Other protein: Fab30 heavy chain, Fab30 light chain,

Peptide ligand: Neurotensin peptide (B)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Neurotensin receptor type 1

Organism: Homo sapiens

Uniprot: P30989

Effector protein

Name: Beta-arrestin-1

Organism: Rattus norvegicus

Uniprot: P29066


Title: A complex structure of arrestin-2 bound to a G protein-coupled receptor.

Authors: Yin W, Li Z, Jin M, Yin YL, de Waal PW, Pal K, Yin Y, Gao X, He Y, Gao J, Wang X, Zhang Y, Zhou H, Melcher K, Jiang Y, Cong Y, Edward Zhou X, Yu X, Eric Xu H

Published: Cell Res (2019)

Other protein (not shown in structure)

Name: Fab30 heavy chain, Fab30 light chain,

Organism: Synthetic construct

Receptor TM helicies
TM regions (from OPM database)

TM1(61-80),2(105-129),3(139-171),TM4( 183-200),TM5( 239-269),TM6( 295-320),TM7( 345-367)

Additional info

Membrane Thickness: 30.6 ± 1.2 Å

Tilt: 39 ± 1°

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