General description

CRF1 Receptor Gs GPCR protein complex with CRF1 peptide


Receptor name: Corticotropin-releasing factor receptor 1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 2.9

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Peptide ligand: Corticoliberin (P)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Corticotropin-releasing factor receptor 1

Organism: Homo sapiens

Uniprot: P34998

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Toward a Structural Understanding of Class B GPCR Peptide Binding and Activation.

Authors: Liang YL, Belousoff MJ, Zhao P, Koole C, Fletcher MM, Truong TT, Julita V, Christopoulos G, Xu HE, Zhang Y, Khoshouei M, Christopoulos A, Danev R, Sexton PM, Wootten D

Published: Mol Cell (2020)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Lama glama

Receptor TM helicies
TM regions (from OPM database)

TM1( 114-139),TM2( 153-176),TM3( 186-215),TM4( 228-249),TM5( 268-292),TM6( 312-329),TM7( 339-365)

Additional info

Membrane Thickness: 30.6 ± 1 Å

Tilt: 10 ± 2°

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