General description

human Neurotensin Receptor 1 (hNTSR1) - Gi1 Protein Complex in canonical conformation (C state)


Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.0

Effector protein: G: α β γ (A B C)

Other protein: scFv16

Peptide ligand: JMV449 (L)

MD preparation


Number of mutations: 1

List of mutations: (R)A85L

Effector protein

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Conformational transitions of a neurotensin receptor 1-G<sub>i1</sub> complex.

Authors: Kato HE, Zhang Y, Hu H, Suomivuori CM, Kadji FMN, Aoki J, Krishna Kumar K, Fonseca R, Hilger D, Huang W, Latorraca NR, Inoue A, Dror RO, Kobilka BK, Skiniotis G

Published: Nature (2019)

Other protein (not shown in structure)

Name: scFv16

Organism: Mus musculus

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