General description

Cryo-EM structure of formyl peptide receptor 2/lipoxin A4 receptor in complex with Gi


Receptor name: N-formyl peptide receptor 2

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.2

Effector protein: G: α β γ (A B C)

Other protein: scFv16

Peptide ligand: Peptide agonist (L)

Non-peptide ligand code: QXV (L)

MD preparation


Number of mutations: 8

List of mutations: (A)G203A (A)A326S (A)D328E (B)Q6E (B)E130Q (B)N237D (C)E17Q (C)E58Q


Name: N-formyl peptide receptor 2

Organism: Homo sapiens

Uniprot: P25090

Effector protein

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Structure of formylpeptide receptor 2-G<sub>i</sub> complex reveals insights into ligand recognition and signaling.

Authors: Zhuang Y, Liu H, Edward Zhou X, Kumar Verma R, de Waal PW, Jang W, Xu TH, Wang L, Meng X, Zhao G, Kang Y, Melcher K, Fan H, Lambert NA, Eric Xu H, Zhang C

Published: Nat Commun (2020)

Other protein (not shown in structure)

Name: scFv16

Organism: Synthetic construct

Receptor TM helicies
TM regions (from OPM database)

TM1( 24-49),TM2( 65-86),TM3( 95-117),TM4( 146-163),TM5( 192-218),TM6( 244-269),TM7( 279-302)

Additional info

Membrane Thickness: 30.2 ± 1.4 Å

Tilt: 11 ± 0°

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