General description

Cannabinoid Receptor 1-G Protein Complex


Receptor name: Cannabinoid receptor 1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.0

Effector protein: G: α β γ (A B C)

Other protein: scFv16

Non-peptide ligand code: KCA (R)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Cannabinoid receptor 1

Organism: Homo sapiens

Uniprot: P21554

Effector protein

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Bos taurus

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Structure of a Signaling Cannabinoid Receptor 1-G Protein Complex.

Authors: Krishna Kumar K, Shalev-Benami M, Robertson MJ, Hu H, Banister SD, Hollingsworth SA, Latorraca NR, Kato HE, Hilger D, Maeda S, Weis WI, Farrens DL, Dror RO, Malhotra SV, Kobilka BK, Skiniotis G

Published: Cell (2019)

Other protein (not shown in structure)

Name: scFv16

Organism: Mus musculus

Receptor TM helicies
TM regions (from OPM database)

TM1( 116-138),TM2( 155-178),TM3( 187-215),TM4( 234-253),TM5( 274-299),TM6( 341-364),TM7( 378-400)

Additional info

Membrane Thickness: 31.4 ± 1.2 Å

Tilt: 18 ± 12°

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