General description

CryoEM structure of human PAC1 receptor in complex with PACAP38


Receptor name: Pituitary adenylate cyclase-activating polypeptide type I receptor

Receptor chain: A

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 3.5

Effector protein: G: α β γ (F E D)

Other protein: Nanobody 35

Peptide ligand: Pituitary adenylate cyclase-activating polypeptide (B)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Pituitary adenylate cyclase-activating polypeptide type I receptor

Organism: Homo sapiens

Uniprot: P41586

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Bos taurus

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Bos taurus

Uniprot: P63212


Title: Cryo-EM structures of PAC1 receptor reveal ligand binding mechanism.

Authors: Wang J, Song X, Zhang D, Chen X, Li X, Sun Y, Li C, Song Y, Ding Y, Ren R, Harrington EH, Hu LA, Zhong W, Xu C, Huang X, Wang HW, Ma Y

Published: Cell Res (2020)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Synthetic construct

Receptor TM helicies
TM regions (from OPM database)

TM1( 155-176),TM2( 188-208),TM3( 227-252),TM4( 268-287),TM5( 304-329),TM6( 347-374),TM7( 380-404)

Additional info

Membrane Thickness: 31.4 ± 1 Å

Tilt: 19 ± 1°

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