General description

Cryo-EM structure of the human glucagon receptor in complex with Gs


Receptor name: Glucagon receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 3.7

Effector protein: G: α β γ (A B C)

Other protein: Nanobody 35

Peptide ligand: Glucagon (E)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Glucagon receptor

Organism: Homo sapiens

Uniprot: P47871

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Structural basis of G<sub>s</sub> and G<sub>i</sub> recognition by the human glucagon receptor.

Authors: Qiao A, Han S, Li X, Li Z, Zhao P, Dai A, Chang R, Tai L, Tan Q, Chu X, Ma L, Thorsen TS, Reedtz-Runge S, Yang D, Wang MW, Sexton PM, Wootten D, Sun F, Zhao Q, Wu B

Published: Science (2020)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Unidentified

Receptor TM helicies
TM regions (from OPM database)

TM1( 139-161),TM2( 178-200),TM3( 220-247),TM4( 268-288),TM5( 303-324),TM6( 376-400)

Additional info

Membrane Thickness: 29.8 ± 1.4 Å

Tilt: 10 ± 1°

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