General description

Cryo-EM structure of a class A GPCR with G protein complex


Receptor name: Cannabinoid receptor 2

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 2.9

Effector protein: G: α β γ (A B C)

Other protein: scFv16

Non-peptide ligand code: 8D0 (R)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Cannabinoid receptor 2

Organism: Homo sapiens

Uniprot: P34972

Effector protein

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Activation and Signaling Mechanism Revealed by Cannabinoid Receptor-G<sub>i</sub> Complex Structures.

Authors: Hua T, Li X, Wu L, Iliopoulos-Tsoutsouvas C, Wang Y, Wu M, Shen L, Johnston CA, Nikas SP, Song F, Song X, Yuan S, Sun Q, Wu Y, Jiang S, Grim TW, Benchama O, Stahl EL, Zvonok N, Zhao S, Bohn LM, Makriyannis A, Liu ZJ

Published: Cell (2020)

Other protein (not shown in structure)

Name: scFv16

Organism: Homo sapiens

Receptor TM helicies
TM regions (from OPM database)

TM1( 35-56),TM2( 71-92),TM3( 107-129),TM4( 151-170),TM5( 189-209),TM6( 248-267),TM7( 280-300)

Additional info

Membrane Thickness: 27.8 ± 1.6 Å

Tilt: 4 ± 1°

Back to table.