General description

Cryo-EM structure of the active, Gs-protein complexed, human CGRP receptor


Receptor name: Calcitonin gene-related peptide type 1 receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 3.3

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Peptide ligand: Calcitonin gene-related peptide 1 (P), Receptor activity-modifying protein 1 (E)

MD preparation


Number of mutations: 8

List of mutations: (A)S54N (A)G226A (A)E268A (A)N271K (A)K274D (A)R280K (A)T284D (A)I285T


Name: Calcitonin gene-related peptide type 1 receptor

Organism: Homo sapiens

Uniprot: Q16602

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Cryo-EM structure of the active, G<sub>s</sub>-protein complexed, human CGRP receptor.

Authors: Liang YL, Khoshouei M, Deganutti G, Glukhova A, Koole C, Peat TS, Radjainia M, Plitzko JM, Baumeister W, Miller LJ, Hay DL, Christopoulos A, Reynolds CA, Wootten D, Sexton PM

Published: Nature (2018)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Lama glama, Homo sapiens

Uniprot: O60894

Receptor TM helicies
TM regions (from OPM database)

TM1( 140-161),TM2( 176-197),TM3( 214-235),TM4( 253-273),TM5( 290-313),TM6( 334-342),TM7( 365-387)

Additional info

Membrane Thickness: 30.2 ± 1 Å

Tilt: 12 ± 2°

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