General description

Mu Opioid Receptor-Gi Protein Complex


Receptor name: Mu-type opioid receptor

Receptor chain: R

Receptor organism: Mus musculus

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.5

Effector protein: G: α β γ (A B C)

Other protein: scFv16

Peptide ligand: DAMGO (D)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Mu-type opioid receptor

Organism: Mus musculus

Uniprot: P42866

Effector protein

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Structure of the ยต-opioid receptor-G<sub>i</sub> protein complex.

Authors: Koehl A, Hu H, Maeda S, Zhang Y, Qu Q, Paggi JM, Latorraca NR, Hilger D, Dawson R, Matile H, Schertler GFX, Granier S, Weis WI, Dror RO, Manglik A, Skiniotis G, Kobilka BK

Published: Nature (2018)

Other protein (not shown in structure)

Name: scFv16

Organism: Mus musculus

Receptor TM helicies
TM regions (from OPM database)

TM1( 69-91),TM2( 106-127),TM3( 138-162),TM4( 186-205),TM5( 227-251),TM6( 283-305),TM7( 313-336)

Additional info

Membrane Thickness: 31.4 ± 2.4 Å

Tilt: 2 ± 3°

Back to table.