General description

Cryo-EM structure of the human adenosine A1 receptor-Gi2-protein complex bound to its endogenous agonist


Receptor name: Adenosine receptor A1

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 3.6

Effector protein: G: α β γ (A B G)

Non-peptide ligand code: ADN (R)

MD preparation


Number of mutations: 4

List of mutations: (A)S47N (A)G204A (A)E246A (A)A327S


Name: Adenosine receptor A1

Organism: Homo sapiens

Uniprot: P30542

Effector protein

Name: Guanine nucleotide-binding protein G(i) subunit alpha-2

Organism: Homo sapiens

Uniprot: P04899

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Structure of the adenosine-bound human adenosine A<sub>1</sub> receptor-G<sub>i</sub> complex.

Authors: Draper-Joyce CJ, Khoshouei M, Thal DM, Liang YL, Nguyen ATN, Furness SGB, Venugopal H, Baltos JA, Plitzko JM, Danev R, Baumeister W, May LT, Wootten D, Sexton PM, Glukhova A, Christopoulos A

Published: Nature (2018)

Receptor TM helicies
TM regions (from OPM database)

TM1( 7-32),TM2( 46-71),TM3( 81-103),TM4( 124-144),TM5( 177-201),TM6( 236-259),TM7( 267-288)

Additional info

Membrane Thickness: 31 ± 1.2 Å

Tilt: 10 ± 0°

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