General description

Rhodopsin-Gi complex


Receptor name: Rhodopsin

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Rhodopsin-like / A

Resolution [Å]: 4.5

Effector protein: G: α β γ (A B G)

Fusion protein: Soluble cytochrome b562

Other protein: Fab Light chain, Fab Heavy chain

MD preparation


Number of mutations: 0

List of mutations: None


Name: Rhodopsin

Organism: Homo sapiens

Uniprot: P08100

Fusion protein

Name: Soluble cytochrome b562

Organism: Escherichia coli

Uniprot: P0ABE7

Effector protein

Name: Guanine nucleotide-binding protein G(i) subunit alpha-1

Organism: Homo sapiens

Uniprot: P63096

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Rattus norvegicus

Uniprot: P54311

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Bos taurus

Uniprot: P63212


Title: Cryo-EM structure of human rhodopsin bound to an inhibitory G protein.

Authors: Kang Y, Kuybeda O, de Waal PW, Mukherjee S, Van Eps N, Dutka P, Zhou XE, Bartesaghi A, Erramilli S, Morizumi T, Gu X, Yin Y, Liu P, Jiang Y, Meng X, Zhao G, Melcher K, Ernst OP, Kossiakoff AA, Subramaniam S, Xu HE

Published: Nature (2018)

Other protein (not shown in structure)

Name: Fab Light chain, Fab Heavy chain

Organism: Synthetic construct

Receptor TM helicies
TM regions (from OPM database)

TM1( 35-60),TM2( 73-99),TM3( 109-134),TM4( 150-173),TM5( 201-223),TM6( 255-278),TM7( 285-308)

Additional info

Membrane Thickness: 31.8 ± 2 Å

Tilt: 12 ± 3°

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