General description

Cryo-EM structure of the activated Glucagon-like peptide-1 receptor in complex with G protein


Receptor name: Glucagon like peptide 1 receptor

Receptor chain: R

Receptor organism: Oryctolagus cuniculus

Family / Class: Secretin / B1

Resolution [Å]: 4.1

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

Peptide ligand: Glucagon-like peptide 1 (P)

MD preparation


Number of mutations: 0

List of mutations: None


Name: Glucagon like peptide 1 receptor

Organism: Oryctolagus cuniculus

Uniprot: G1SGD4

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Rattus norvegicus

Uniprot: P54311

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Bos taurus

Uniprot: P63212


Title: Cryo-EM structure of the activated GLP-1 receptor in complex with a G protein.

Authors: Zhang Y, Sun B, Feng D, Hu H, Chu M, Qu Q, Tarrasch JT, Li S, Sun Kobilka T, Kobilka BK, Skiniotis G

Published: Nature (2017)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Lama glama

Receptor TM helicies
TM regions (from OPM database)

TM1( 144-164),TM2( 179-200),TM3( 224-249),TM4( 268-290),TM5( 304-329),TM6( 350-372),TM7( 379-404)

Additional info

Membrane Thickness: 30.6 ± 1.6 Å

Tilt: 12 ± 4°

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