General description

Volta phase plate cryo-electron microscopy structure of a calcitonin receptor-heterotrimeric Gs protein complex


Receptor name: Calcitonin receptor

Receptor chain: R

Receptor organism: Homo sapiens

Family / Class: Secretin / B1

Resolution [Å]: 4.1

Effector protein: G: α β γ (A B G)

Other protein: Nanobody 35

MD preparation


Number of mutations: 0

List of mutations: None


Name: Calcitonin receptor

Organism: Homo sapiens

Uniprot: P30988

Effector protein

Name: Guanine nucleotide-binding protein G(s) subunit alpha isoforms short

Organism: Homo sapiens

Uniprot: P63092

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

Organism: Homo sapiens

Uniprot: P62873

Name: Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2

Organism: Homo sapiens

Uniprot: P59768


Title: Phase-plate cryo-EM structure of a class B GPCR-G-protein complex.

Authors: Liang YL, Khoshouei M, Radjainia M, Zhang Y, Glukhova A, Tarrasch J, Thal DM, Furness SGB, Christopoulos G, Coudrat T, Danev R, Baumeister W, Miller LJ, Christopoulos A, Kobilka BK, Wootten D, Skiniotis G, Sexton PM

Published: Nature (2017)

Other protein (not shown in structure)

Name: Nanobody 35

Organism: Lama glama

Receptor TM helicies
TM regions (from OPM database)

TM1( 147-172),TM2( 182-203),TM3( 221-242),TM4( 259-281),TM5( 298-317),TM6( 346-360),TM7( 370-393)

Additional info

Membrane Thickness: 30.2 ± 1 Å

Tilt: 13 ± 0°

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